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4/29/2024 0 Comments Disney baby dumboAfter getting back down to the ground while falling from the tree, Timothy wonders if Dumbo either jumped or climbed up to the tree until he finally comes to believe that Dumbo flew (due to one of the crows' ironic suggestion), thus, amusing the crows and making them sing " When I See an Elephant Fly". When they awaken, they somehow end up in a tree after meeting some crows, who are amused by an elephant being in a tree and tell them about their situation. Dumbo uses his trunk to blow bubbles for Timothy to play with, but shortly after, they both begin hallucinating, seeing Pink Elephants. Later, Dumbo and Timothy accidentally become drunk when they drink water that has been accidentally mixed with champagne due to the clowns' clumsiness. To cheer him up, Timothy takes Dumbo to visit his mother, but the visit ends too soon. The failure results in the circus making Dumbo into a clown, which depresses him and makes him a real laughingstock to the circus, the people, the clowns, and the other elephants. The first attempt ends in failure, as Dumbo once again accidentally trips on his ears while attempting to jump to the top of a "Pyramid of Pachyderms" as the climax results in collapsing the big top and all the elephants become injured, he then emerges his trunk through a hole on the big top swinging his flag, but it breaks in half due to the collapse of the big top leaving him swinging what's left of his flag. Having overheard the teasing Dumbo endures earlier, Timothy decides to help Dumbo become a circus star. When Dumbo tries to have a hay meal with the other female elephants, they give him the cold shoulder, and he walks away without a friend in the world until he meets his soon-to-be best friend, Timothy, whom he was afraid of at first when Timothy scared all the elephants for picking on Dumbo, but then, Dumbo and Timothy become friends when Timothy offers to help him get his mother out of the clink. Dumbo is left by himself feeling sad, while the other elephants laugh at him and regard him a disgrace. When his mother tries to protect him, she is believed to be mad, and is captured and imprisoned by the Ringmaster and his guards. Once people come into the circus for a tour to see the circus animals, Dumbo gets laughed at by some boy bullies and his ears are pulled by a boy who wanted to tease him, thus, considered a laughingstock to them. A few moments later, Dumbo is given a bath by his mother, and they spend time playing with one another. The next day, Dumbo takes part in the opening parade for the circus with his mother and the other elephants, but accidentally trips on his ears and falls in a mud puddle, thus, causing everyone to laugh at him. Dumbo later takes part in setting up the circus tent with his mother and the other elephants and circus animals at night as they arrive at their destination. After Dumbo's mother closes the door to their stalls, she wraps up Dumbo in his own ears, and they rest peacefully. ![]() As soon as his big ears are revealed, he is teased by the other female elephants, who call him "Dumbo". The baby elephant then sneezes after the Elephant Matriarch tickles him on his trunk and reveals that his ears are much larger than average. Jumbo, and all the other female elephants remark on his cute looks. In his debut, after being delivered by a stork, he is named "Jumbo, Jr." by his mother Mrs. ![]() Dumbo wears a small yellow conical hat, which Timothy uses as a seat to ride the elephant standing inside the brim, and a red clown collar with a yellow central stripe. He has a small proboscis with two large nostrils at the end of it. He has big ears (which the other elephants don't like), but he uses them to fly. His skin is gray, his eyes are blue, and his tail is very small. ![]() However, in Dumbo's Circus, he does talk when he's a teenager.ĭumbo is a small Asian elephant. However, he is also very open-hearted, such as with Timothy and the Crows, and never seemed to express any true anger or resentment toward those who tease him.Īs he is only a baby in his first appearance, he does not talk during the film, save for some quick squeaks. Dumbo is also very easily scared, evidenced by his encounters with the clowns, the pink elephants, and, like all elephants, Timothy Mouse. He is somewhat naïve, as he did not realize Smitty and his gang were taunting him or that the " magic feather" was simply a way of thinking. He is playful, innocent, fun-loving, and loves being around his mother and hates being alone. Dumbo has the personality of a small child. 4/29/2024 0 Comments Sector 5 delco dispatch![]() Stressful Work Environment: Dispatch operators operate under high-pressure situations, dealing with distressing calls and critical decisions. Delco Dispatc’h must invest in state-of-the-art communication systems and software to stay ahead of evolving challenges. Technological Limitations: Keeping up with technological advancements is essential for a dispatch center to operate seamlessly. Managing this influx requires a well-trained and efficient staff. High Call Volume: With the population of Delaware County growing steadily, Delco Dispatc’h often faces high call volumes, especially during peak hours or significant events. Some of the common hurdles faced by dispatch centers include: While Delco Dispatch plays a pivotal role in ensuring public safety, it is not without its challenges. The center maintains constant communication with first responders, relaying updates and critical information to enhance their effectiveness on the ground. Delco Dispatch utilizes advanced technologies to track the location of emergency service units, ensuring the nearest and most appropriate responders are dispatched to the scene.Ĭoordination with First Responders: Delco Dispatch serves as a liaison between emergency services and those in need. Resource Allocation: Efficient allocation of resources is crucial during emergencies. Call operators at the dispatch center are trained to handle distress calls, extracting critical information to assess the situation and dispatch appropriate services promptly. The Responsibilities of Delco Dispatch:Įmergency Call Handling: Delco Dispatch is the first point of contact for individuals facing emergencies. Operating 24/7, Delco Dispatch acts as a vital link between those in need and the first responders equipped to address various emergencies. It is a sophisticated system that receives, processes, and dispatches emergency calls for police, fire, and medical assistance. Understanding Delco Dispatch:ĭelco Dispatch, short for Delaware County Dispatch, serves as the communication hub for emergency services in the region. ![]() Recognizing and supporting Delco Dispatch’s vital work ensures the pulse of Delaware County remains steady, safeguarding the well-being of its residents. The seamless coordination between dispatchers and first responders enhances overall safety and security in Delaware County. Highly trained professionals handle emergencies, practice effective communication, and make split-second decisions that can save lives.ĭelco Dispatch’s role in community safety is significant, contributing to reducing crime rates, minimizing property damage, and saving lives. However, the human element is crucial to its effectiveness. The center uses cutting-edge technology, such as computer-aided dispatch (CAD) systems, geographic information systems (GIS), and integrated communication platforms, to enhance its operations. ![]() Challenges faced by Delco Dispatch include high call volumes, technological limitations, and a stressful work environment. Delco Dispatch’s responsibilities include emergency call handling, resource allocation, and coordination with first responders. It receives, processes, and dispatches emergency calls for police, fire, and medical assistance, operating 24/7. Delco Dispatch, or Delaware County Dispatch, is a vital communication hub for emergency services in Delaware County, ensuring the safety and well-being of residents by efficiently coordinating emergency responses and public services. ![]() If you missed something that recently happened click the "Feed Archives" button above and listen to the event as it unfolded.In the heart of Delaware County, a lifeline pulses through the community, connecting citizens, emergency services, and essential resources seamlessly. The primary purpose of this feed is to keep the residents and business owners informed about what is happening in the community. The feed is broadcasted from 19026 with a Uniden BC125AT scanner. Broadcasting Delaware County Police Sector 5 which operates on 508.11250 MHz frequency. 4/29/2024 0 Comments The flaming grill buffet prices![]() ![]() : 10 Las Vegas restaurants where you can still dine old-school style ![]() Omelet meets Italian food with this plate-sized monster ($12.95), a gigantic cloud of eggs bursting with two kinds of cheese, sausage and mushrooms. Las Vegas Weekly: Bite Now: The Maserati at Peppermill Since 1972, tourists and locals alike have sought refuge in the plush, rope-lit banquettes of this campy, comfy North Strip coffee shop and cocktail lounge. The Peppermill, located between the Riviera and the Wynn, has been open for more than 40 years. Las Vegas Review Journal: 9 Best Places for a First Date in Las Vegas What has fun food, tons of history, and is pink and blue and neon all over? If you know Las Vegas, you know the answer is Peppermill Restaurant and Fireside Lounge. When you step inside the Peppermill, you don’t really see a lot of things that remind you of tomatoes with celery. What has become a time-warp anomaly burst upon Vegas’s restaurant universe on December 26, 1972-as the Vietnam War dragged on and neckties were wider than a baby’s bib. The Peppermill exists within a space-time continuum of its own creation. Vegas Magazine: The Peppermill Celebrates 40 years of Big Eats The Peppermill on the Strip is a Las Vegas classic, and worth the drive down there. ![]() Las Vegas Review Journal: 14 bars every Las Vegas local needs to try A short walk from Wynncore, SLS, Circus Circus and more. Huffington Post: 20 Great happy hours on the Las Vegas stripĬlassic Vegas - everyone should go here, deal or no deal. Las Vegas Weekly: 24 Hours Inside The Peppermillīig Foods, crazy cocktails, and undeniable warmth: A day in the life of a strip institution This place is a Vegas classic that remains unique even though it’s kind of trapped itself in 1976. In fact, Peppermill is where the 1995 Scorsese crime drama, Casino was filmed. Visiting this restaurant and lounge is probably the closest one can get to being in an old-school Vegas movie. The Travel: Livin' La Vida Breakfast: Where To Find A Meal After A Long Night In Vegas The kitsch is strong at the Peppermill, a diner that's been around since 1972 and seems to be everybody's favorite place on the Strip to grab eggs and pancakes in the middle of the night. Thrillist: 12 Old-School Las Vegas Restaurants with Classic Interiors No, it’s what the cover of Duran Duran’s Rio would look like serving punchbowl-sized drinks. Las Vegas Weekly: A Tour of Eye-Catching Vegas Bar Interiors We encourage guests to take alternative transportation if possible. Peppermill Las Vegas has limited parking. Special pricing on well drinks, select beers, and house wines, as well as half-priced select appetizers. OPEN 24 HOURS FRIDAY, SATURDAY, SUNDAY Happy HourĮnjoy Happy Hour every day from 3pm - 6pm. Open Monday - Wednesday: 7am - 2am. Last seating at 1:15am. Call ahead seating is available if we have are over an hour wait.Restaurant reservations are accepted by calling after 4pm for present and future dates.Take I-15 to West Sahara Blvd, turn right on Las Vegas Blvd.Ģ985 Las Vegas Blvd ( View Map). A timeless must-visit stop on the Las Vegas strip! The Peppermill Restaurant and Lounge is a classic with a cool atmosphere, unique drinks, and amazing food & desserts! Come see why the Peppermill has been featured in numerous movies!Ĭentrally located on Las Vegas Blvd between the Wynn and Resorts World, next to Ross. 4/29/2024 0 Comments Camino de santiago route maps![]() The Camino de Santiago has also been officially recognized by the Council of Europe and UNESCO for its historical and spiritual significance. Many follow its routes primarily for religious and spiritual reasons, others however are moved by the desire to get away from their daily life and connect with nature. It is one of the world's most famous pilgrimage routes, with over 300,000 people undertaking the journey each year. James the Great in the Cathedral of Santiago de Compostela in Galicia, in northwestern Spain, where tradition has it that the remains of the saint are buried. James) is the name of any of the pilgrimage routes to the shrine of the Apostle St. Rediscovering the world step by step with our hiking guides If you only have time for a week of walking, take a look at our comfortable Camino Inglés itinerary (6 days).A practical guide with detailed route maps Or, walk from Irún and connect to Oviedo from Villaviciosa for a rugged, but beautiful and historic, itinerary combining the Camino del Norte and Camino Primitivo. However, you can start walking the Camino anywhere along the route. This route is the Full Camino Frances and takes approximately 35 days to complete. The mountainous terrain is not for the faint-of-heart but fit walkers can manage this route in two weeks.Ĭonsider walking from Irún to Santiago on one of our various Camino del Norte itineraries. The starting point of the Camino Frances is the French town of St Jean Pied de Port at the foot of the Pyrenees, for instance, 800kms away from Santiago. Our Camino Primitivo itinerary is 13 days from Oviedo to Santiago. Walk all the way from Lisboa (26 days) or start from Porto and continue to Santiago on the central, coastal, and/or spiritual routes for a manageable two-week journey. The discovery of the tomb of the Apostle in the 9th century marked the beginning of a Camino that leads our steps to Santiago until today. There are numerous Camino Portugués intineraries. The Camino de Santiago is one of the most important pilgrimage routes in Europe. View three itineraries of varying length to complete the Camino Francés (26 days, 31 days, 40 days). How much time do you have to walk? Is it important for you to reach Santiago? What aspect of the Camino are you most interested in (mountain scenery, good wine, camaraderie)?.The bridge has been integrated into the modern Camino Francés. The Norte and Primitivo routes are more remote and so better suited for camping than the Francés route. Roman bridge with 19 arches over the river Órbigo. On all routes, in Galicia (where pilgrim traffic is heaviest), albergues are generally more frequently spaced and well organized. In Portugal, pilgrims have been known to stay in fire stations or share rooms in simple pensions on the Camino del Norte, select municipal buildings or gyms are open to pilgrims during the high season (July/August) and on the Camino Primitivo, in Asturias, old schoolhouses have been repurposed as albergues. Similarly, the style of albergue can be less formalized on routes other than the Francés. ![]() The Camino Portugués, Camino del Norte, Camino Primitivo and Camino Inglés routes all have reasonably-spaced albergues however, distances between albergues are greater in places than on the Francés, and some private accommodations may be necessary. The Camino Francés is the best set up for staying in inexpensive dormitory pilgrim accommodations each night, as there are many hostels and very frequent distances. Do you want to stay in pilgrim accommodations (inexpensive hostels) or do you prefer to have private accommodations, or to camp?.On every route, the last 100km to Santiago can become crowded! I have started this thread to serve as a point of conversation for the Camino Guides Beta that was launched last month. On other less frequented camino routes (Camino Portugués south of Porto, Camino del Norte, Camino Primitivo, Camino Inglés), you’ll still encounter other pilgrims, but you’re more likely to have time to yourself, walking alone throughout the day. The Camino Portuguésis also quite popular north of Porto. The Camino Francés route is very popular and you are guaranteed to walk with many others during the popular seasons. Do you want to walk with other people, or by yourself?.Here are a few questions to help guide your exploration: Some of the routes don’t actually finish in Santiago, but will joins other Camino roads that will end in the cathedral of Santiago. Many people travel this distance, but there are also other popular starting points for the Camino Francés, including Pamplona, Burgos, León, Ponferrada and Sarria. Jean Pied de Port, France to Santiago de Compostela, Spain. It covers 800 kilometers (500 miles) from St. With the many pilgrimage routes available in Spain, Portugal, and France, it can be overwhelming to choose which route is right for you. The map features of 50 Camino de Santiago routes through Spain and Portugal. The Camino Francés is by far the most popular. Pilgrim Associations & Online Resources. 4/29/2024 0 Comments Missouri tick identification![]() ![]() Rebecca Smith/KBIA Deb Hudman has collected thousands of ticks during her career, and she developed a system for "flagging," where she can interchange the flannel sheets used to collect ticks between sites. Serious illness can be prevented in most cases by treatment with the antibiotic doxycycline within days of symptoms. “Usually they'll present with high fever, real high like 104 degrees, bad headache, aches all over plus (or) minus a rash,” Roland said. He added that while some symptoms can be very specific to each disease - like spots for Rocky Mountain Spotted Fever, a skin ulcer for Tularemia or the well-known bullseye rash of Lyme disease - almost all tick-borne bacterial diseases begin the same. Roland said they do see cases of Lyme, as well as Alpha-Gal, which is an allergy to red meat caused by a bite from a Lone Star tick. According to the Centers for Disease Control and Prevention, Missouri is one of the hotspots for both Ehrlichiosisand Rocky Mountain Spotted Fever - ranking among the top five states for both illnesses. He said the most common tick-borne illnesses in Missouri are Ehrlichiosis, Tularemia and Rocky Mountain Spotted Fever. So, these can lead to death when not treated, or (when) improperly treated.” “That being said, we have seen patients fever more than 60 days with Ehrlichiosis. “These are more acute illnesses, they're not associated with long-term morbidity or mortality,” Roland said. William Roland, a professor of clinical medicine and an infectious disease expert with MU Health Care, said not everyone who gets bit by a tick will contract a disease and develop symptoms.īut even if they do, most are mild illnesses that usually only present serious problems for those who are older than 40, very young or immunocompromised. William Roland, an infectious disease doctor with MU Health Care, said if someone comes in with "flu-like symptoms" in the summer and has been spending time outside – he and others will prescribe the antiobiotic doxyclincie, which can prevent the onset of severe tick-borne illness. If it's viral, well, then you're just on for the ride anyways.” "So, the diagnosis is not that hugely important. “The good news is that with all of these bacterial pathogens, they're all treated the same," Hudman said. ![]() Bacterial diseases like Ehrlichiosis, Rocky Mountain Spotted Fever, Southern Tick-Associated Rash Illness, and Lyme disease, as well as several viral infections like Bourbon virus and Heartland virus. The study, Hudman notes, was limited by what ticks were sent in, but many tick diseases were found to be present in Missouri. She said it’s important for Missourians to note that ticks are more than just a “woods problem,” as they were found throughout the state – not just in rural areas. In total, Hudman said that at least two ticks were submitted from every county and 17,466 usable ticks were submitted through the mail. She added that 71% of those were Lone Star tick, 26% were the American Dog tick, 2% were the Blacklegged (Deer tick) and the remaining 1% consisted of five different species. This tick is know to transmit diseases like Ehrlichiosis, Southern Tick-Associated Rash Illness (STARI), Tularemia, the Bourbon and Heartland viruses, as well as the red meat allergy caused by a tick bite called Alpha Gal. Rebecca Smith/KBIA / The Lone Star tick is the most common tick in Missouri and the female of the species is easily recognized by the white spot on it's back. 4/28/2024 0 Comments Arduino mega 2560 rev3 ground pins![]() To control the voltage provided to the Arduino board, as well as to stabilize the DC voltage used by the processor and other components.Ĭonvert an external input DC7-12V voltage into DC 5V, then switch DC 5V to the processor and other components.Īrduino board can be supplied with an external power DC7-12V from the DC power jack. It tells us that the frequency is 16,000,000 Hertz or 16MHz. The number printed on the top of the Arduino crystal is 16.000H9H. How does Arduino calculate time? by using a crystal oscillator. When Arduino board communicates via serial port, receive the message, RX led flashes. Onboard you can find the label: RX(receive ) When Arduino board communicates via serial port, send the message, TX led flashes. Onboard you can find the label: TX (transmit) USB to serial chip, can convert the USB signal into serial port signal. ![]() When the pin is HIGH value, the LED is on, when the pin is LOW, it's off. There is a built-in LED driven by digital pin 13. the value used as the top of the input range).Īrduino board can be powered via USB connector.Īll you needed to do is connecting the USB port to PC using a USB cable. Used with analogReference().Ĭonfigures the reference voltage used for analog input (i.e. Reference voltage (0-5V) for analog inputs. Using pinMode(), digitalWrite(), and digitalRead() functions. Or used as digital output pin to drive different modules like LED, relay, etc. These pins can be configured as digital input pin to read the logic value (0 or 1). Here is an explanation of what every element and interface of the board does:Īrduino MEGA has 54 digital input/output pins (of which 15 can be used as PWM outputs). Flash Memory: 256 KB of which 8 KB used by bootloader.To facilitate wiring, a 0.5 m USB wire is provided for you. We can power on by USB wire, DC head and Vin GND pins. This chip is burnt the firmware well before leaving the factory, therefore, we hardly use it. The built-in ICSP port can burn the firmware for ATMEGA2560-16AU directly. It has 54 digital input/output pins (of which 15 can be used as PWM outputs), 16 analog inputs, 4 UARTs (hardware serial ports), a 16 MHz crystal oscillator, a USB connection, a power jack, 1 ICSP header, and a reset button. Keyestudio Mega 2560 R3 is a microcontroller board based on the ATMEGA2560-16AU, fully compatible with ARDUINO MEGA 2560 R3. 6.3 How to Install the Driver of CP2102. 4/28/2024 0 Comments Google chrome won't download filesToggle the switch to the right to enable this feature. Then scroll to the bottom to find the PDF documents. Under Privacy and security, select Site Setting. Scroll the screen down and click Advanced. Step to open the panel of Customize and control Google Chrome. Another way is to set up Chrome to download pdf files instead of automatically opening them so that it will be downloaded when you try to open the PDF file online. If you want to download this PDF file, you can click on the download link provided by Gmail. For example, if your Google mailbox receives an email with a PDF attachment, you can click on the PDF directly, and Chrome will automatically open the file for you online. With the default settings, Chrome automatically calls the built-in pdf viewer to open the pdf file. More Tip: Download pdf files instead of automatically opening them in chrome If not, try to use other browsers to download the PDF file. If you don't have the authorization, you can request it from their website.Īfter troubleshooting, it is a problem that can be solved and resumes Chrome PDF download not working. Check if the PDF file has permission issues. Make sure the network is connected and the network speed is stable. Try to close the security software when you download the PDF files in chrome. These seem to be irrelevant but may be the reason why your Chrome can't download PDF files. Some computer security, anti-virus, protection software will affect the Chrome browser to download files. ![]() As it said, it will disable all extensions and clear temporary data.Ĭheck Internet Network & Shutdown antivirus software of computer Chrome can find harmful software (which may cause your PDF download not working) on your Computer and remove it. Chrome's download settings can be updated to the latest Chrome version. Remove some extensions, which may cause conflict when you try to download PDF. There're kinds of extensions you might add to your Chrome. Then reload the download page, and try to download it again. How to Fix Chrome PDF download not working Fix the PDF files not downloading error in Chrome
4/28/2024 0 Comments Free script fonts with glyphs![]() ![]() ![]() And occasionally, sou will see this logo for OpenType-SVG: The SVG table was mainly developed, and pushed, by Mozilla and Adobe. Fonts containing such an SVG table are most commonly referred to as OpenType-SVG, sometimes as SVG-in-OT, or simply as SVG color font. What makes OpenType fonts OpenType fonts is their internal structure, which is a collection of so-called OpenType tables, and one of these tables can be the SVG table, containing SVG-based information. Its desktop siblings, CFF/OTFs and TTFs, are also OpenType formats, both with their peculiarities and not as well-compressed as WOFF. There is more to it of course, but in a nutshell, WOFFs are compressed OpenType fonts. The webfont file formats in wide use today are WOFF and WOFF2. This tutorial is not about the deprecated legacy SVG font file format. Glyphs is an OpenType font editor, and therefore cannot produce SVG fonts like these. In other words, it was not even an OpenType font. That means: no kerning, no hinting, and none of the other good things OpenType tables can provide. Its filesize was huge compared to other font formats, and it offered nothing but plain outlines. Forget about it right away, because it was only really supported by Safari on early iPhones. SVG font formatįirstly, there used to be SVG as a webfont file format. So far, so good, but when we use the term in the realm of fonts, it can actually mean different things. When you look up SVG, you will find that it stands for Scalable Vector Graphics. 4/28/2024 0 Comments Higgins india ink non toxic![]() ![]() For example, pathogenic species belonging to the phylum Chytridiomycota have been shown to be a major factor leading to the extinction of multiple amphibian species. In recent years, however, this perception has changed rapidly, and there is growing concern about the threats posed by fungi to animals and humans. ![]() Viral and bacterial infections tend to be the pathogens that receive the most attention, especially for their potential to cause pandemics accordingly, human fungal pathogens and IFDs have long been underrecognized. ![]() In addition, people with underlying diseases including diabetes mellitus, liver or kidney disease, chronic obstructive pulmonary disease, and viral respiratory tract infections, have been newly identified as an at-risk population. People most at risk of invasive fungal disease (IFD) are those with a compromised immune system, due to HIV infection, chemotherapy and immunotherapy for cancer, solid organ transplantation, or other factors. The development of novel management strategies through the identification of new drug targets and the discovery and optimization of new and existing diagnostics and therapeutics are key to reducing the health burden.Įmerging fungal pathogens and infections pose increasing threats to global public health. Emphasis should be placed on further understanding the mechanisms of pathogenicity and of antifungal resistance and tolerance. neoformans is compounded by accumulating evidence for its ability to infect immunocompetent individuals and the emergence of antifungal-resistant variants. Unfortunately, diagnostic and treatment options for cryptococcal infections are limited, and emerging antifungal resistance exacerbates the public health burden. The incidences of CM in Europe and North America and the Latin America region have increased by approximately two-fold since 2009, while other regions showed either reduced or stable numbers of cases. However, cryptococcal meningitis still accounts for 19% of AIDS-related deaths annually. There has been a general reduction in the estimated global burden of HIV-associated cryptococcal meningitis since 2009, probably due to improvements in highly active antiretroviral therapies. Finally, we summarized knowledge regarding the resistance and tolerance of C. We then reviewed recent updates on the diagnosis and antifungal treatment of cryptococcal infections. We next conducted scoping reviews in accordance with the guidelines described in the Preferred Reporting Items for Systematic Reviews and Meta-analyses extension for Scoping Reviews using PubMed and ScienceDirect with the keyword Cryptococcus neoformans to identify case reports of cryptococcal infections published since 2000. We first reviewed trends in the global burden of HIV-associated cryptococcal infection, mainly based on a series of systematic studies. The purpose of this review is to drive research efforts to improve future diagnoses, therapies, and interventions associated with fungal infections. Taking the highest-ranked fungal pathogen in the FPPL, Cryptococcus neoformans, as a paradigm, we review progress made over the past two decades on its global burden, its clinical manifestation and management of cryptococcal infection, and its antifungal resistance. The World Health Organization has responded to the rising threat of traditionally neglected fungal infections by developing a Fungal Priority Pathogens List (FPPL). Emerging fungal pathogens pose important threats to global public health. |
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